Dysplastic nevus
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ໃນປີ 2022 Stiftung Warentest ຜົນໄດ້ຮັບຈາກເຢຍລະມັນ, ຄວາມພໍໃຈຂອງຜູ້ບໍລິໂພກກັບ ModelDerm ແມ່ນຕໍ່າກວ່າການປຶກສາຫາລືທາງດ້ານການປິ່ນປົວທາງໂທລະສັບເລັກນ້ອຍເທົ່ານັ້ນ.
Dysplastic nevi - Biopsy ແມ່ນແນະນໍາສໍາລັບຊາວຕາເວັນຕົກ.
relevance score : -100.0%
ReferencesDysplastic nevus, ເຊິ່ງເອີ້ນກັນວ່າ atypical ຫຼື Clarks nevus, ໄດ້ກະຕຸ້ນການໂຕ້ວາທີ່ຢູ່ພະຍາດຜິວ (dermatology) ແລະ ພະຍາດຜິວພາບຜິວ (dermatopathology). ແພດມັກຈະກວນຮ່າງກາຍຂອງ ຕົ້ນຜິວ (moles) ເຫຼົ່ານີ້ເພາະວ່າພວກມັນມີລັກສະນະຜິດປົກກະຕິແລະເຮັດໃຫ້ເກີດຄວາມກັງວົນກ່ຽວກັບ melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , ເຊິ່ງເອີ້ນກັນວ່າ atypical ຫຼື Clark nevi, ບາງຄັ່ງສາມາດນໍາໄປສູ່ການ melanoma. ປະມານ 36% ຂອງ melanomas ແມ່ນພົບເຫັນຢູ່ໃກ້ກັບ dysplastic nevi. ອາການທີ່ບົ່ງບອກວ່າ dysplastic nevus ອາດຈະກາຍເປັນ melanoma ປະກອບມີຮູບຮ່າງບໍ່ສະຫມໍ່າສະເຫມີ, ການປ່ຽນແປງເມັດສີຫຼາຍ, ຫຼືສີສີຂີ້ເຖົ່າ. ມະເຮັງເຫຼົານີ້ມັກຈະເກີດຂຶ້ນໃນອາຍຸຍັງນ້ອຍ (ປະມານກາງສາມສິບ), ສາມາດມີຫຼາຍ, ແລະມັກຈະຢູ່ໃນລໍາຕົ້ນ. ທາງພັນທຸກໍ່, dysplastic nevi ແມ່ນຢູ່ໃນລະຫວ່າງ benign nevi ແລະ melanoma. ແນວໃດກໍ່ຕາມ, ພຽງແຕ່ 20% ຫາ 30% ຂອງ melanomas ມາຈາກ nevi ທີ່ມີຢອດແລ້ວ. ເນື່ອງຈາກ nevi ສ່ວນໃຫຍ່ບໍ່ກາຍເປັນ melanoma, ມັນມັກຈະບໍ່ແນຍນໍາໃຫ້ເອົາພວກມັນອອກເພື່ອປ້ອງກັນ.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma ແມ່ນປະເພດຂອງເນື້ອງອກທີ່ປະກອບໃນເວລາທີ່ ເຊວຊີດສີຜິວ (melanocytes), ຈຸລັງທີ່ຮັບຜິດຊອບຕໍ່ສີຜິວ, ກາຍເປັນມະເຮັງ. ເຊວຊີດສີຜິວມີຕົ້ນກໍາເນີດມາຈາກ ແຂນປະສາດ (neural crest). ນີ້ຫມາຍຄວາມວ່າ melanoma ສາມາດພັດທະນາບໍ່ພຽງແຕ່ຢູ່ໃນຜິວຫນັງ, ແຕ່ຍັງຢູ່ໃນພື້ນທີ່ອື່ນໆທີ່ຈຸລັງ ແຂນປະສາດ (neural crest) ເຄື່ອນຍ້າຍ, ເຊັ່ນ: ກະເພາະລໍາໄສ້ແລະສະຫມອງ. ອັດຕາການຢູ່ລອດຂອງຄົນເຈັບທີ່ເປັນໂຣກ melanoma ໃນໄລຍະຕົ້ນ (ໄລຍະ 0) ແມ່ນສູງຢູ່ທີ່ 97%, ໃນຂະນະທີ່ມັນຫຼຸດລົງຢ່າງຫຼວງຫຼາຍເຖິງປະມານ 10% ສໍາລັບຜູ້ທີ່ຖືກກວດພົບວ່າເປັນໂຣກກ້າວຫນ້າ (ໄລຍະ IV).
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ ສ່ຽງເປັນມະເຮັງ
ດັ່ງທີ່ເຫັນຢູ່ໃນບຸກຄົນ Caucasian ໃນສະຫະລັດ, ຜູ້ທີ່ມີ dysplastic nevi ມີຄວາມສ່ຽງຕະຫຼອດຊີວິດຂອງການພັດທະນາ ມລານອັດ (melanoma) ຫຼາຍກ່ວາ 10%. ໃນທາງກົງກັນຂ້າມ, ຜູ້ທີ່ບໍ່ມີ dysplastic nevus ມີຄວາມສ່ຽງຕໍ່ການພັດທະນາ ມລານອັດ (melanoma) ຫນ້ອຍກວ່າ 1%.
○ ຂໍ້ຄວນລະວັງສຳລັບບຸກຄົນທີ່ມີ dysplastic nevi
ການກວດຕົນເອງຕາມຜິວຜິວປົກກະຕິແລ້ວແມ່ນແນະນຳເພື່ອປ້ອງກັນການເກີດເນື້ອງອກ (ໂດຍການລະບຸ nevi atypical ທີ່ສາມາດເອົາອອກໄດ້) ຫຼືເພື່ອກວດຫາເນື້ອງອກທີ່ມີຢູ່ກ່ອນກຳນົດ. ຄົນທີ່ມີປະຫວັດສ່ວນຕົວ ຫຼືຄອບຄົວເປັນມະເຮັງຜິວຜິວ (melanoma) ຫຼືເປັນມະເຮັງຜິວຜິວຫຼາຍຊະນິດຄວນໄປພົບແພດຜິວຜິວຢ່າງໜ້ອຍປີລາຄາດເພື່ອໃຫ້ແນ່ໃຈວ່າເຂົາບໍ່ເປັນມະເຮັງຜິວຜິວ.
ຕົວຫຍໍ້ [ABCDE] ໄດ້ເປັນປະໂຫຍດສໍາລັບການຊ່ວຍໃຫ້ຜູ້ໃຫ້ບໍລິການດ້ານສຸຂະພາບແລະພະນັກງານຈື່ຈໍາລັກສະນະທີ່ສໍາຄັນຂອງ ມລານອັດ (melanoma). ແຕ່ຫນ້າເສຍດາຍສໍາລັບຄົນໂດຍສະເລ່ຍ, ກະດູກຜິວຜິວ (seborrheic keratoses) ຫຼາຍ, ບາງການສະແດງຜິວອາຍຸ (lentigo senilis), ແລະກະດູກຕຸ່ມ (warts) ອາດຈະມີລັກສະນະ [ABCDE], ແລະບໍ່ສາມາດຈໍາແນກຈາກ ມລານອັດ (melanoma) ໄດ້.
○ [ABCDE]
Asymmetrical: ຜິວຜິວບໍ່ສົມດຸນ.
Border: ຊາຍແດນຂອງ lesion ແມ່ນສະຫມໍ່າສະເຫມີ.
Color: ມລານອັດ (melanoma) ປົກກະຕິແລ້ວມີຫຼາຍສີທີ່ບໍ່ສະຫມໍ່າສະເຫມີ.
Diameter: nevi ຫຼາຍກວ່າ 6 ມມ ມັກຈະເປັນ ມລານອັດ (melanoma) ຫຼາຍກວ່າ nevi ຂະໜາດນ້ອຍກວ່າ.
Evolution: ການວິວັດທະນາການ (i.e. ການປ່ຽນແປງ) ຂອງ nevus ຫຼື lesion ອາດຈະຊີ້ໃຫ້ເຫັນວ່າ lesion ກາຍເປັນ malignant.