Dysplastic nevus
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Dysplastic nevi - Biopsy ແມ່ນແນະນໍາສໍາລັບຊາວຕາເວັນຕົກ.
relevance score : -100.0%
ReferencesDysplastic nevus, ເຊິ່ງເອີ້ນກັນວ່າ atypical ຫຼື Clarks nevus, ໄດ້ກະຕຸ້ນການໂຕ້ວາທີ່ຢູ່ dermatology ແລະ dermatopathology. ແພດມັກຈະກວດຮ່າງກາຍຂອງ moles ເຫຼົ່ານີ້ເພາະວ່າພວກມັນມີລັກສະນະຜິດປົກກະຕິ ແລະ ເຮັດໃຫ້ເກີດຄວາມກັງວົນກ່ຽວກັບ melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi, ເຊິ່ງເອີ້ນກັນວ່າ atypical ຫຼື Clark nevi, ບາງຄັ້ງສາມາດນໍາໄປສູ່ melanoma. ປະມານ 36% ຂອງ melanomas ແມ່ນພົບເຫັນໃກ້ກັບ dysplastic nevi. ອາການທີ່ບອກວ່າ dysplastic nevus ອາດຈະກາຍເປັນ melanoma ປະກອບມີຮູບຮ່າງບໍ່ສະແດງອອກ, ການປ່ຽນແປງເມັດສີຫຼາຍ, ຫຼືສີຂີ້ເຖົ່າ. ອັນເຫຼົ່ານີ້ມັກເກີດໃນອາຍຸຍັງນ້ອຍ (ປະມານກາງສາມສິບ), ສາມາດມີຫຼາຍກວ່າ, ແລະມັກຢູ່ໃນລໍາຕົ້ນ. ທາງພາບທຸກຂໍ້, dysplastic nevi ແມ່ນຢູ່ລະຫວ່າງ nevi benign ແລະ melanoma. ແນວໃດກໍ່ຕາມ, ພຽງແຕ່ 20% ຫາ 30% ຂອງ melanomas ມາຈາກ nevi ທີ່ມີຢູ່ແລ້ວ. ເນື່ອງຈາກ nevi ສ່ວນໃຫຍ່ບໍ່ກາຍເປັນ melanoma, ມັນມັກຈະບໍ່ແນະນໍາໃຫ້ຖອກອອກເພື່ອປ້ອງກັນ.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma ແມ່ນປະເພດຂອງເນື້ອງອກທີ່ມີ melanocytes ຈຸລັງຮັບຜິດຊອບຕໍ່ສີຜິວ ແລະ ກາຍເປັນມະເຮັງ. Melanocytes ມີຕົ້ນກໍາເນີດຈາກເສັ້ນປະສາດ neural crest. ນີ້ແຈ້ງວ່າ melanomas ສາມາດພັດທະນາບໍ່ແຕ່ໃນຜິວຫນັງ ແຕ່ຍັງໃນພື້ນທີ່ອື່ນໆທີ່ຈຸລັງ neural crest ເຄື່ອນຍ້າຍ ເຊັ່ນ ກະເພາະລໍາໄສ້ ແລະ ສະຫມອງ. ອັດຕາການຢູ່ລອດຂອງຄົນເຈັບທີ່ມີ melanoma ໃນໄລຍະຕົ້ນ (ໄລຍະ 0) ສູງສຸດທີ່ 97%, ແລະ ຕໍ່ມາຫຼຸດລົງເຖິງປະມານ 10% ສໍາລັບຜູ້ທີ່ຖືກກວດພົບເປັນໂຣກກ້າວຫນ້າ (ໄລຍະ IV).
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ ສ່ຽງເປັນມະເຮັງ
ຕາມການສຶກສາສ່ວນໃຫຍ່ໃນຜູ່ຄົນ Caucasian ທີ່ອາ່ຍຸ່ນຢູ່ສະຫະລັດ, ຜູ່ທີ່ມີ dysplastic nevi ມີຄວາມສ່ຽງຕໍ່ການພັດທະນາ melanoma ສູງກວ່າ 10%. ຕໍ່ຕາມ, ຜູ່ທີ່ບໍ່ມີ dysplastic nevus ມີຄວາມສ່ຽງຕໍ່ melanoma ຕໍ່ກວ່າ 1%.
○ ຂໍ້ຄວນລະວັງສຳລັບຜູ່ຄົນທີ່ມີ dysplastic nevi
ການກວດສອບຕົນເອງຕາມການສັ່ງແນະນໍາຂອງຜູ່ພະຍາດຜິວຜັນ ແມ່ນວິທີປ້ອງກັນການເກີດຂອງ nevi atypical ທີ່ອາດຈະປ່ຽນເປັນມະເຮັງ (ການລະບຸ) ຫຼືເພື່ອກວດຫາມະເຮັງທີ່ມີຢູ່ກ່ອນແລ້ວ. ຜູ່ທີ່ມີປະຫວັດສ່ວນຕົວ ຫຼືມີຄອບຄົວເປັນມະເຮັງຜິວຜັນ ຫຼືມີປະຫວັດມະເຮັງຜິວຜັນຫຼາຍຊັ້ນ, ຄວນໄປພົບແພດຜິວຜັນຢ່າງນ້ອຍປີລາວກັນທຽບເພື່ອແນ່ໃຈວ່າບໍ່ແມ່ນມະເຮັງຜິວຜັນ.
ຕົວຢ່າງ [ABCDE] ເປັນເຄື່ອງມືທີ່ຊ່ວຍພະນັກງານສຸຂພາບ ແລະຜູ່ບໍລິການກວດສອບ melanoma ໄດ້ດີຂຶ້ນ. ແຕ່ການໃຊ້ງານຂອງມັນອາດຈະສ່ຽງກັບການຕັດສິນໃນກໍລະນີທີ່ມີ keratoses seborrheic ຫຼາຍ, ບາງ lentigo senilis, ຫຼືແມ່ກະທັ້ງຕຸ່ມອາດຈະມີລັກສະນະ [ABCDE] ແລະບໍ່ສາມາດແຍກຈາກ melanoma ໄດ້.
○ [ABCDE]
Asymmetrical: ຜິວໜັງບໍ່ສອດຄ້ອຍ.
Border: ຊາຍແດນຂອງ lesion ບໍ່ສະໝໍ່າສະເຫມີ.
Color: melanoma ມັກຈະມີສີຫຼາຍທີ່ບໍ່ສະໝໍ່າສະເຫມີ.
Diameter: nevi ທີ່ຂະໜາດໃຫຍ່ກວ່າ 6 ມມ ມັກຈະເປັນ melanoma ແພງກວ່າ nevi ຂະໜາດນ້ອຍ.
Evolution: ການປ່ຽນແปງ (i.e. evolution) ຂອງ nevus ຫຼື lesion ອາດຊີ້ໃຫ້ເບິ່ງໄດ້ວ່າ lesion ເປັນ malignant.